Victor H. Negrón, Jr. attended the United States Military Academy at West Point, concluding his undergraduate education with the receipt of a bachelor of arts degree, magna cum laude, in May 1975, from St. Mary's University, San Antonio, Texas. He went on to receive his juris doctor degree in May 1978 from St. Mary's University School of Law. He is admitted to practice before the United States Supreme Court. Negrón is married and has four sons. His eldest, Victor III, recently returned from serving in the Army Infantry near Fallujah, in Iraq.

He is currently a partner with the firm of Kerr & Negrón, P.C., having joined with his partner following his tenure as judge of the 407th District Court. Previously, Negrón had been a sole practitioner for approximately ten years.

His community and Bar involvement include holding office as a director and treasurer, as well as membership as the chair of the Fee Dispute committee, and membership in various other committees of the San Antonio Bar Association. Negrón is board certified in family law by the Texas Board of Legal Specialization. He is also a member of the Texas Family Law Council, where he has served on the Form Book and Pro Bono committees. Other memberships include the Family Law section of the State Bar of Texas, the State Bar's Judicial section, the San Antonio Family Lawyers Association (president 1992 and 2003) and was a founding member and first president of the Alamo Council of Termination & Adoption Attorneys. Negrón is a trained mediator and also handles arbitrations. He has been a faculty member of the State Bar of Texas' Advanced Family Law Course (9 years), lecturing on a variety of topics of interest to family law practitioners. He was Co-Director of the 2005 Advanced Family Law Course. He has been a frequent lecturer at St. Mary's University School of Law and has authored and spoken on no fewer than 15 articles ranging from adoption to discovery.

Negrón's prior legal experience includes several years with the Bexar County Legal Aid Association, where his commitment to pro bono work was forged. He has carried that commitment into his service on the Texas Family Law Council 's Pro Bono committee, as well as frequent participation as both on-site and off-site mentor of the Bar Association's Community Justice Program.

His military service has included time as both an enlisted member and a captain in the Judge Advocate General's Corps of the Texas Army National Guard, with numerous awards and decorations. He is active in the Catholic Church as a frequent speaker, and his community involvement includes (or has included) membership on the boards of the following organizations: Child Guidance Center, Any Baby Can (Program Development committee), Bexar County Domestic Relations Office advisory board (chair).  He has also served as an assistant scoutmaster in the Boy Scouts of America, a two-time volunteer in the Susan G. Kommen Breast Cancer Foundation Race for the Cure and a YMCA coach.